https://rauscha.github.io/Dialog-podcast A weekly peer-level digest of the most important new maternal-fetal medicine research, with Juno and Caspar. en Juno & Caspar false Juno & Caspar podcast@andrewrausch.com
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Empiric Reflex
2. 1:02 — Headline Setup: Who's in the Room
3. 2:04 — Headline Deep Dive: Effect Size and What It Means
4. 3:05 — Round 1: Proteinuria Severity and Long-Term Cardiorenal Risk (BJOG)
5. 4:07 — Round 2: Semaglutide Into Pregnancy (Green Journal)
6. 5:09 — Round 3: 22-Week Survival and the Intervention Bundle (AJOG MFM)
7. 6:11 — Round 4: FMF Calibration Across Conception Modes (Ultrasound Obstet Gynecol)
8. 7:13 — What to Watch / Still Unsettled
9. 8:14 — Sign-Off

Follow-up links:

• First-trimester prediction and prevention of preterm pre-eclampsia in women with chronic hypertension. - Provides RCT-level evidence that biomarker-driven first-trimester screening and aspirin prophylaxis delay preterm preeclampsia in chronic hypertensives—directly informing whether to screen universally or treat empirically.
• Gestational Weight Gain and Pregnancy Outcomes After Semaglutide Exposure. - First large propensity-matched EMR analysis linking ongoing semaglutide use into pregnancy with adverse outcomes, sharpening preconception counseling for patients on GLP-1 agonists.
• Proteinuria in Preeclampsia and Long-Term Risk of Maternal Kidney and Cardiovascular Disease: A Population-Based Cohort Study. - Quantifies how proteinuria severity at preeclampsia diagnosis predicts decades-long maternal cardiorenal risk, enabling more individualized postpartum surveillance.
• Improving 1-Year Survival at 22 Weeks Gestation: Which Perinatal Interventions Matter? - Identifies specific interventions—steroids, ventilation, surfactant—that independently improve one-year survival at 22 weeks, strengthening evidence-based periviability counseling.
• Predictive performance of Fetal Medicine Foundation first-trimester screening algorithm for pre-eclampsia according to conception mode. - Demonstrates that FMF preeclampsia screening calibration varies by ART versus spontaneous conception, prompting context-specific interpretation in fertility-treatment pregnancies.

Episode companion data]]>
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Empiric Reflex
2. 1:02 — Headline Setup: Who's in the Room
3. 2:04 — Headline Deep Dive: Effect Size and What It Means
4. 3:05 — Round 1: Proteinuria Severity and Long-Term Cardiorenal Risk (BJOG)
5. 4:07 — Round 2: Semaglutide Into Pregnancy (Green Journal)
6. 5:09 — Round 3: 22-Week Survival and the Intervention Bundle (AJOG MFM)
7. 6:11 — Round 4: FMF Calibration Across Conception Modes (Ultrasound Obstet Gynecol)
8. 7:13 — What to Watch / Still Unsettled
9. 8:14 — Sign-Off

Follow-up links:

• First-trimester prediction and prevention of preterm pre-eclampsia in women with chronic hypertension. - Provides RCT-level evidence that biomarker-driven first-trimester screening and aspirin prophylaxis delay preterm preeclampsia in chronic hypertensives—directly informing whether to screen universally or treat empirically.
• Gestational Weight Gain and Pregnancy Outcomes After Semaglutide Exposure. - First large propensity-matched EMR analysis linking ongoing semaglutide use into pregnancy with adverse outcomes, sharpening preconception counseling for patients on GLP-1 agonists.
• Proteinuria in Preeclampsia and Long-Term Risk of Maternal Kidney and Cardiovascular Disease: A Population-Based Cohort Study. - Quantifies how proteinuria severity at preeclampsia diagnosis predicts decades-long maternal cardiorenal risk, enabling more individualized postpartum surveillance.
• Improving 1-Year Survival at 22 Weeks Gestation: Which Perinatal Interventions Matter? - Identifies specific interventions—steroids, ventilation, surfactant—that independently improve one-year survival at 22 weeks, strengthening evidence-based periviability counseling.
• Predictive performance of Fetal Medicine Foundation first-trimester screening algorithm for pre-eclampsia according to conception mode. - Demonstrates that FMF preeclampsia screening calibration varies by ART versus spontaneous conception, prompting context-specific interpretation in fertility-treatment pregnancies.

Sources:

• First-trimester prediction and prevention of preterm pre-eclampsia in women with chronic hypertension. - Ultrasound Obstet Gynecol - 2026 (https://doi.org/10.1002/uog.70212)
• Gestational Weight Gain and Pregnancy Outcomes After Semaglutide Exposure. - Obstet Gynecol - 2026 (https://doi.org/10.1097/aog.0000000000006325)
• Proteinuria in Preeclampsia and Long-Term Risk of Maternal Kidney and Cardiovascular Disease: A Population-Based Cohort Study. - BJOG - 2026 (https://doi.org/10.1111/1471-0528.70265)
• Improving 1-Year Survival at 22 Weeks Gestation: Which Perinatal Interventions Matter? - Am J Obstet Gynecol MFM - 2026 (https://doi.org/10.1016/j.ajogmf.2026.101989)
• Predictive performance of Fetal Medicine Foundation first-trimester screening algorithm for pre-eclampsia according to conception mode. - Ultrasound Obstet Gynecol - 2026 (https://doi.org/10.1002/uog.70244)

Original synthetic theme music generated locally for this episode.

Episode companion data]]> Tue, 02 Jun 2026 01:48:04 +0000 d117a53269b5f78dc6ab1bfdf91d7f96d0f38351d807ac44114974a9f59bf1f3 10:01 false
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Surveillance Gap
2. 0:52 — Headline: Design and Population
3. 1:44 — Headline: Effect Size and the Gestational Age Gradient
4. 2:36 — Headline: Confounding, Causation, and the Shared Risk Factor Problem
5. 3:27 — Headline: Practice Impact and What Remains Unsettled
6. 4:19 — Round 1: Nakaki / Fetal Brain MRI
7. 5:11 — Round 2: Mari / TTTS Expert Synthesis
8. 6:03 — Round 3: Shrestha / Metformin Effect Modification
9. 6:55 — Round 4: Sorrenti / sFGR Diagnostic Criteria
10. 7:47 — Close: What to Watch, What Is Still Unsettled

Follow-up links:

• Spontaneous Preterm Birth and Subsequent Cardiovascular Mortality: Linked Registry Cohort Study - Large population cohort demonstrating 2-3x higher cardiovascular mortality after sPTB, supporting long-term CV surveillance
• Effects of Mediterranean diet and stress-reduction interventions during pregnancy on fetal brain development detected using magnetic resonance imaging - RCT substudy showing detectable fetal brain MRI differences with lifestyle intervention, though small sample limits conclusions
• Twin-Twin Transfusion Syndrome and Related Monochorionic Disorders: Historical Perspectives, Current Controversies, and Evidence-Based Opportunities - Authoritative synthesis of TTTS diagnostic variability, staging controversies, and laser therapy evidence
• The effect of metformin on perinatal outcomes in pregnant women with type 2 diabetes differs by baseline insulin requirements - Secondary RCT analysis suggesting metformin benefit varies by insulin requirements, potentially guiding personalized T2D management
• Perinatal outcome of monochorionic twin pregnancy complicated by selective fetal growth restriction: ISUOG vs Delphi diagnostic criteria - 24-year cohort showing Delphi sFGR criteria better predict adverse outcomes than ISUOG definition in MCDA twins

Episode companion data]]>
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Surveillance Gap
2. 0:52 — Headline: Design and Population
3. 1:44 — Headline: Effect Size and the Gestational Age Gradient
4. 2:36 — Headline: Confounding, Causation, and the Shared Risk Factor Problem
5. 3:27 — Headline: Practice Impact and What Remains Unsettled
6. 4:19 — Round 1: Nakaki / Fetal Brain MRI
7. 5:11 — Round 2: Mari / TTTS Expert Synthesis
8. 6:03 — Round 3: Shrestha / Metformin Effect Modification
9. 6:55 — Round 4: Sorrenti / sFGR Diagnostic Criteria
10. 7:47 — Close: What to Watch, What Is Still Unsettled

Follow-up links:

• Spontaneous Preterm Birth and Subsequent Cardiovascular Mortality: Linked Registry Cohort Study - Large population cohort demonstrating 2-3x higher cardiovascular mortality after sPTB, supporting long-term CV surveillance
• Effects of Mediterranean diet and stress-reduction interventions during pregnancy on fetal brain development detected using magnetic resonance imaging - RCT substudy showing detectable fetal brain MRI differences with lifestyle intervention, though small sample limits conclusions
• Twin-Twin Transfusion Syndrome and Related Monochorionic Disorders: Historical Perspectives, Current Controversies, and Evidence-Based Opportunities - Authoritative synthesis of TTTS diagnostic variability, staging controversies, and laser therapy evidence
• The effect of metformin on perinatal outcomes in pregnant women with type 2 diabetes differs by baseline insulin requirements - Secondary RCT analysis suggesting metformin benefit varies by insulin requirements, potentially guiding personalized T2D management
• Perinatal outcome of monochorionic twin pregnancy complicated by selective fetal growth restriction: ISUOG vs Delphi diagnostic criteria - 24-year cohort showing Delphi sFGR criteria better predict adverse outcomes than ISUOG definition in MCDA twins

Sources:

• Welters et al. - BJOG - 2026 - Spontaneous Preterm Birth and Subsequent Cardiovascular Mortality: Linked Registry Cohort Study (https://doi.org/10.1111/1471-0528.70273)
• Nakaki et al. - Ultrasound Obstet Gynecol - 2026 - Effects of Mediterranean diet and stress-reduction interventions during pregnancy on fetal brain development detected using magnetic resonance imaging (https://doi.org/10.1002/uog.70214)
• Mari et al. - Am J Obstet Gynecol - 2026 - Twin-Twin Transfusion Syndrome and Related Monochorionic Disorders: Historical Perspectives, Current Controversies, and Evidence-Based Opportunities (https://doi.org/10.1016/j.ajog.2026.05.021)
• Shrestha et al. - Am J Obstet Gynecol - 2026 - The effect of metformin on perinatal outcomes in pregnant women with type 2 diabetes differs by baseline insulin requirements (https://doi.org/10.1016/j.ajog.2026.04.043)
• Sorrenti et al. - Ultrasound Obstet Gynecol - 2026 - Perinatal outcome of monochorionic twin pregnancy complicated by selective fetal growth restriction: ISUOG vs Delphi diagnostic criteria (https://doi.org/10.1002/uog.70239)

Original synthetic theme music generated locally for this episode.

Episode companion data]]> Wed, 03 Jun 2026 05:39:39 +0000 4c690c5a60bfe5dda48d6a35b7f241af40dc65ab8b2642024c61504cf2294cdf 9:24 false
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Clinical Question That Moved
2. 0:52 — Headline: Clinical Question and Why a Meta-Analysis Earns the Grade
3. 1:43 — Headline: Effect Size and the Pre-Selection Gradient
4. 2:35 — Headline: Caveats — Heterogeneity and VUS
5. 3:27 — Headline: Practice Impact
6. 4:18 — Round 1: Stampalija / Single-Cell Trophoblast Sequencing
7. 5:10 — Round 2: Cruz-Martínez / Latin American FETO
8. 6:02 — Round 3: Sileo / Early TTTS Laser
9. 6:53 — Round 4: Kim DeLuca / cfDNA and SCA Detection
10. 7:45 — Close: What's Still Unsettled

Follow-up links:

• Diagnostic Yield of Sequencing for Prenatal Diagnosis of Fetal Structural Anomalies: An Updated Systematic Review - Provides pooled evidence for sequencing yield over CMA in structurally abnormal fetuses, directly informing when to offer exome or genome sequencing
• Single-cell-based non-invasive screening for fetal pathogenic microimbalances using maternal blood - Demonstrates that single-cell trophoblast sequencing can detect submicroscopic CNVs non-invasively, potentially reducing need for amniocentesis
• Latin American Multicenter Study of Fetal Endoscopic Tracheal Occlusion for Severe Left Diaphragmatic Hernia - Largest Latin American FETO dataset confirms survival benefit and extends outcome benchmarks beyond European and North American centers
• Perinatal outcomes of twin pregnancies complicated by early twin-to-twin transfusion syndrome treated with fetoscopic laser surgery - Largest early-TTTS laser series provides stage-specific survival data for counseling families facing intervention before 18 weeks
• Impact of Prenatal Cell-Free DNA Screening on Sex Chromosome Aneuploidy Diagnoses in Infants and Children - Population-level evidence that cfDNA screening has shifted SCA detection earlier, changing the timing and burden of counseling and subspecialty referral

Episode companion data]]>
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Clinical Question That Moved
2. 0:52 — Headline: Clinical Question and Why a Meta-Analysis Earns the Grade
3. 1:43 — Headline: Effect Size and the Pre-Selection Gradient
4. 2:35 — Headline: Caveats — Heterogeneity and VUS
5. 3:27 — Headline: Practice Impact
6. 4:18 — Round 1: Stampalija / Single-Cell Trophoblast Sequencing
7. 5:10 — Round 2: Cruz-Martínez / Latin American FETO
8. 6:02 — Round 3: Sileo / Early TTTS Laser
9. 6:53 — Round 4: Kim DeLuca / cfDNA and SCA Detection
10. 7:45 — Close: What's Still Unsettled

Follow-up links:

• Diagnostic Yield of Sequencing for Prenatal Diagnosis of Fetal Structural Anomalies: An Updated Systematic Review - Provides pooled evidence for sequencing yield over CMA in structurally abnormal fetuses, directly informing when to offer exome or genome sequencing
• Single-cell-based non-invasive screening for fetal pathogenic microimbalances using maternal blood - Demonstrates that single-cell trophoblast sequencing can detect submicroscopic CNVs non-invasively, potentially reducing need for amniocentesis
• Latin American Multicenter Study of Fetal Endoscopic Tracheal Occlusion for Severe Left Diaphragmatic Hernia - Largest Latin American FETO dataset confirms survival benefit and extends outcome benchmarks beyond European and North American centers
• Perinatal outcomes of twin pregnancies complicated by early twin-to-twin transfusion syndrome treated with fetoscopic laser surgery - Largest early-TTTS laser series provides stage-specific survival data for counseling families facing intervention before 18 weeks
• Impact of Prenatal Cell-Free DNA Screening on Sex Chromosome Aneuploidy Diagnoses in Infants and Children - Population-level evidence that cfDNA screening has shifted SCA detection earlier, changing the timing and burden of counseling and subspecialty referral

Sources:

• Lim et al. - Prenat Diagn - 2026 - Diagnostic Yield of Sequencing for Prenatal Diagnosis of Fetal Structural Anomalies: An Updated Systematic Review (https://doi.org/10.1002/pd.70112)
• Stampalija et al. - Ultrasound Obstet Gynecol - 2026 - Single-cell-based non-invasive screening for fetal pathogenic microimbalances using maternal blood (https://doi.org/10.1002/uog.70201)
• Cruz-Martínez et al. - Prenat Diagn - 2026 - Latin American Multicenter Study of Fetal Endoscopic Tracheal Occlusion for Severe Left Diaphragmatic Hernia (https://doi.org/10.1002/pd.70175)
• Sileo et al. - Ultrasound Obstet Gynecol - 2026 - Perinatal outcomes of twin pregnancies complicated by early twin-to-twin transfusion syndrome treated with fetoscopic laser surgery (https://doi.org/10.1002/uog.70196)
• Kim DeLuca - Prenat Diagn - 2026 - Impact of Prenatal Cell-Free DNA Screening on Sex Chromosome Aneuploidy Diagnoses in Infants and Children (https://doi.org/10.1002/pd.70190)

Original synthetic theme music generated locally for this episode.

Episode companion data]]> Wed, 03 Jun 2026 05:49:27 +0000 72865287a4127e4599151192bdee92f5041f15c5fc71868c5838ddf7f8fa22b1 9:22 false
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: What This Week's Headline Changes
2. 0:53 — Headline: Citation, Design, and Why the RCT Backbone Matters
3. 1:45 — Headline: Effect Sizes and Subgroup Interactions
4. 2:38 — Headline: Practice Impact and the Honest Caveat
5. 3:30 — Round 1: Maiter, Lung Cancer AI Head-to-Head
6. 4:23 — Round 2: Bahl, Breast Tomosynthesis Slab Reconstruction
7. 5:15 — Round 3: Zhang, Mamba Architecture pCR Prediction
8. 6:08 — Round 4: Liu, Radiomics for CMS4 Colorectal Subtyping
9. 7:01 — Close: Open Questions and Sign-Off

Follow-up links:

• Reperfusion Therapy in ESCAPE-MeVO Trial Participants: Imaging Characteristics and Clinical Outcomes - RCT-anchored imaging subgroup analysis in MeVO stroke; informs thrombectomy patient selection
• Independent Head-to-Head Comparison of Commercial Artificial Intelligence Devices for Lung Cancer Detection on Chest Radiographs - Independent benchmarking of commercial AI tools; directly informs deployment decisions
• Impact of AI-based Slab Reconstruction Technology on the Diagnostic Accuracy of Screening Digital Breast Tomosynthesis - Workflow optimization in breast imaging screening with maintained diagnostic performance
• Deep learning prediction of pathological complete response in breast cancer using Mamba architecture - Multicenter external validation of pCR prediction; relevant to neoadjuvant treatment planning
• Interpretable MRI-based Multiparametric Radiomics for Preoperative Prediction of CMS4 Colorectal Cancer - Preoperative molecular subtyping could inform surgical and systemic therapy planning

Episode companion data]]>
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: What This Week's Headline Changes
2. 0:53 — Headline: Citation, Design, and Why the RCT Backbone Matters
3. 1:45 — Headline: Effect Sizes and Subgroup Interactions
4. 2:38 — Headline: Practice Impact and the Honest Caveat
5. 3:30 — Round 1: Maiter, Lung Cancer AI Head-to-Head
6. 4:23 — Round 2: Bahl, Breast Tomosynthesis Slab Reconstruction
7. 5:15 — Round 3: Zhang, Mamba Architecture pCR Prediction
8. 6:08 — Round 4: Liu, Radiomics for CMS4 Colorectal Subtyping
9. 7:01 — Close: Open Questions and Sign-Off

Follow-up links:

• Reperfusion Therapy in ESCAPE-MeVO Trial Participants: Imaging Characteristics and Clinical Outcomes - RCT-anchored imaging subgroup analysis in MeVO stroke; informs thrombectomy patient selection
• Independent Head-to-Head Comparison of Commercial Artificial Intelligence Devices for Lung Cancer Detection on Chest Radiographs - Independent benchmarking of commercial AI tools; directly informs deployment decisions
• Impact of AI-based Slab Reconstruction Technology on the Diagnostic Accuracy of Screening Digital Breast Tomosynthesis - Workflow optimization in breast imaging screening with maintained diagnostic performance
• Deep learning prediction of pathological complete response in breast cancer using Mamba architecture - Multicenter external validation of pCR prediction; relevant to neoadjuvant treatment planning
• Interpretable MRI-based Multiparametric Radiomics for Preoperative Prediction of CMS4 Colorectal Cancer - Preoperative molecular subtyping could inform surgical and systemic therapy planning

Sources:

• Ospel et al. - Radiology - 2026 - Reperfusion Therapy in ESCAPE-MeVO Trial Participants: Imaging Characteristics and Clinical Outcomes (https://doi.org/10.1148/radiol.251769)
• Maiter et al. - Radiology - 2026 - Independent Head-to-Head Comparison of Commercial Artificial Intelligence Devices for Lung Cancer Detection on Chest Radiographs (https://doi.org/10.1148/radiol.252205)
• Bahl et al. - Radiology - 2026 - Impact of AI-based Slab Reconstruction Technology on the Diagnostic Accuracy of Screening Digital Breast Tomosynthesis (https://doi.org/10.1148/radiol.252685)
• Zhang et al. - NPJ Digital Medicine - 2026 - Deep learning prediction of pathological complete response in breast cancer using Mamba architecture (https://doi.org/10.1038/s41746-026-02849-2)
• Liu et al. - Radiology - 2026 - Interpretable MRI-based Multiparametric Radiomics for Preoperative Prediction of CMS4 Colorectal Cancer (https://doi.org/10.1148/radiol.251719)

Original synthetic theme music generated locally for this episode.

Episode companion data]]> Wed, 03 Jun 2026 05:58:49 +0000 8fe782935698398b4308245f1ca4ea958c9c45234e4bb32c187b76d1fd7e7041 8:38 false
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — COLD OPEN: What Changed This Week
2. 0:51 — HEADLINE: Design and Population
3. 1:42 — HEADLINE: Effect Size and the Causation Problem
4. 2:33 — HEADLINE: Practice Impact and the Prior Coverage Note
5. 3:23 — ROUND 1: Keller — Resolved Early FGR and Neonatal Morbidity
6. 4:14 — ROUND 2: Hannoun — Anti-HLA Antibodies and FGR
7. 5:05 — ROUND 3: Kabiri — Late Short Cervix and Progesterone (Affectionate Disagreement)
8. 5:56 — ROUND 4: Ambia — Breakthrough Eclampsia on Magnesium
9. 6:47 — CLOSE: What to Watch, What's Still Open

Follow-up links:

• Changing trends in prenatal screening and treatment of cytomegalovirus infection in France: 7-year national cohort study (2017-2023) - First large-scale national validation that valacyclovir reduces vertical CMV transmission outside trial conditions
• Neonatal morbidity following resolution of fetal growth restriction diagnosed at second-trimester anatomy ultrasound - Challenges the assumption that growth normalization after early FGR confers normal neonatal outcomes
• Anti-HLA Antibodies and Risk of Fetal Growth Restriction - Provides mechanistic insight into immune-mediated unexplained FGR with population-level data
• Vaginal progesterone and risk of preterm birth in asymptomatic women with short cervix diagnosed after 24 weeks of gestation - Directly addresses a common clinical dilemma with sobering signal about late-window progesterone efficacy
• Eclampsia despite magnesium sulfate prophylaxis - Characterizes a clinically important failure-mode population and associated morbidity

Episode companion data]]>
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — COLD OPEN: What Changed This Week
2. 0:51 — HEADLINE: Design and Population
3. 1:42 — HEADLINE: Effect Size and the Causation Problem
4. 2:33 — HEADLINE: Practice Impact and the Prior Coverage Note
5. 3:23 — ROUND 1: Keller — Resolved Early FGR and Neonatal Morbidity
6. 4:14 — ROUND 2: Hannoun — Anti-HLA Antibodies and FGR
7. 5:05 — ROUND 3: Kabiri — Late Short Cervix and Progesterone (Affectionate Disagreement)
8. 5:56 — ROUND 4: Ambia — Breakthrough Eclampsia on Magnesium
9. 6:47 — CLOSE: What to Watch, What's Still Open

Follow-up links:

• Changing trends in prenatal screening and treatment of cytomegalovirus infection in France: 7-year national cohort study (2017-2023) - First large-scale national validation that valacyclovir reduces vertical CMV transmission outside trial conditions
• Neonatal morbidity following resolution of fetal growth restriction diagnosed at second-trimester anatomy ultrasound - Challenges the assumption that growth normalization after early FGR confers normal neonatal outcomes
• Anti-HLA Antibodies and Risk of Fetal Growth Restriction - Provides mechanistic insight into immune-mediated unexplained FGR with population-level data
• Vaginal progesterone and risk of preterm birth in asymptomatic women with short cervix diagnosed after 24 weeks of gestation - Directly addresses a common clinical dilemma with sobering signal about late-window progesterone efficacy
• Eclampsia despite magnesium sulfate prophylaxis - Characterizes a clinically important failure-mode population and associated morbidity

Sources:

• Coste-Mazeau et al. - Ultrasound Obstet Gynecol - 2026 - Changing trends in prenatal screening and treatment of cytomegalovirus infection in France: 7-year national cohort study (2017-2023) (https://doi.org/10.1002/uog.70223)
• Keller et al. - Am J Obstet Gynecol MFM - 2026 - Neonatal morbidity following resolution of fetal growth restriction diagnosed at second-trimester anatomy ultrasound (https://doi.org/10.1016/j.ajogmf.2026.102020)
• Hannoun et al. - Am J Obstet Gynecol - 2026 - Anti-HLA Antibodies and Risk of Fetal Growth Restriction (https://doi.org/10.1016/j.ajog.2026.05.019)
• Kabiri et al. - Am J Obstet Gynecol MFM - 2026 - Vaginal progesterone and risk of preterm birth in asymptomatic women with short cervix diagnosed after 24 weeks of gestation (https://doi.org/10.1016/j.ajogmf.2026.102012)
• Ambia et al. - Am J Obstet Gynecol MFM - 2026 - Eclampsia despite magnesium sulfate prophylaxis (https://doi.org/10.1016/j.ajogmf.2026.102022)

Original synthetic theme music generated locally for this episode.

Episode companion data]]> Tue, 09 Jun 2026 10:08:54 +0000 4f113afcc2eb042c8456423dc798d8361373728644ab05c199450341254cbdb8 8:23 false
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Clinical Problem
2. 0:38 — Headline: Design and Clinical Question
3. 1:17 — Headline: Effect Size and the Heterogeneity Problem
4. 1:55 — Headline: Practice Impact and What Tertiary Centers Can Do Now
5. 2:33 — Pivot and Round 1: Baucom, Twin Chorionicity and Maternal Morbidity
6. 3:11 — Round 2: Houri, Preeclampsia Phenotyping
7. 3:50 — Round 3: Miodownik, Placental Syndromes and Long-Term Risk
8. 4:28 — Round 4: Huynh, Vasa Previa Hospitalization Guidelines
9. 5:06 — Close: What to Watch, What Is Still Unsettled

Follow-up links:

• Hemodynamics-guided treatment of hypertensive disorders of pregnancy: systematic review and meta-analysis - Meta-analysis of RCTs showing hemodynamics-guided antihypertensive management reduces composite adverse outcomes versus BP-threshold-only care — potentially practice-changing for HDP treatment
• Severe maternal morbidity and obstetrical outcomes by twin chorionicity and amnionicity - Large national database quantifying substantially higher severe maternal morbidity in MCDA and MCMA twins versus dichorionic or singleton gestations
• Phenotyping Preeclampsia Using Unsupervised Machine Learning: A Prospective Cohort Study - Identifies three clinically distinct preeclampsia phenotypes with different severity, angiogenic profiles, and delivery timing — hypothesis-generating for individualized management
• Expert Review: Pregnancy Placental Syndromes and the Effects on Long-Term Health - Synthesizes evidence that placental syndromes predict long-term cardiovascular, renal, and metabolic risk — actionable for postpartum counseling and surveillance
• Hospitalization for Vasa Previa: a Review of National Guidelines - Reveals inconsistent international guidelines on antenatal hospitalization for vasa previa, clarifying that current practice rests on weak evidence

Episode companion data]]>
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Clinical Problem
2. 0:38 — Headline: Design and Clinical Question
3. 1:17 — Headline: Effect Size and the Heterogeneity Problem
4. 1:55 — Headline: Practice Impact and What Tertiary Centers Can Do Now
5. 2:33 — Pivot and Round 1: Baucom, Twin Chorionicity and Maternal Morbidity
6. 3:11 — Round 2: Houri, Preeclampsia Phenotyping
7. 3:50 — Round 3: Miodownik, Placental Syndromes and Long-Term Risk
8. 4:28 — Round 4: Huynh, Vasa Previa Hospitalization Guidelines
9. 5:06 — Close: What to Watch, What Is Still Unsettled

Follow-up links:

• Hemodynamics-guided treatment of hypertensive disorders of pregnancy: systematic review and meta-analysis - Meta-analysis of RCTs showing hemodynamics-guided antihypertensive management reduces composite adverse outcomes versus BP-threshold-only care — potentially practice-changing for HDP treatment
• Severe maternal morbidity and obstetrical outcomes by twin chorionicity and amnionicity - Large national database quantifying substantially higher severe maternal morbidity in MCDA and MCMA twins versus dichorionic or singleton gestations
• Phenotyping Preeclampsia Using Unsupervised Machine Learning: A Prospective Cohort Study - Identifies three clinically distinct preeclampsia phenotypes with different severity, angiogenic profiles, and delivery timing — hypothesis-generating for individualized management
• Expert Review: Pregnancy Placental Syndromes and the Effects on Long-Term Health - Synthesizes evidence that placental syndromes predict long-term cardiovascular, renal, and metabolic risk — actionable for postpartum counseling and surveillance
• Hospitalization for Vasa Previa: a Review of National Guidelines - Reveals inconsistent international guidelines on antenatal hospitalization for vasa previa, clarifying that current practice rests on weak evidence

Sources:

• Novelli et al. - Ultrasound Obstet Gynecol - 2026 - Hemodynamics-guided treatment of hypertensive disorders of pregnancy: systematic review and meta-analysis (https://doi.org/10.1002/uog.70250)
• Baucom et al. - Am J Obstet Gynecol MFM - 2026 - Severe maternal morbidity and obstetrical outcomes by twin chorionicity and amnionicity (https://doi.org/10.1016/j.ajogmf.2026.101993)
• Houri et al. - BJOG - 2026 - Phenotyping Preeclampsia Using Unsupervised Machine Learning: A Prospective Cohort Study (https://doi.org/10.1111/1471-0528.70262)
• Miodownik et al. - Am J Obstet Gynecol MFM - 2026 - Expert Review: Pregnancy Placental Syndromes and the Effects on Long-Term Health (https://doi.org/10.1016/j.ajogmf.2026.102008)
• Huynh et al. - Am J Obstet Gynecol MFM - 2026 - Hospitalization for Vasa Previa: a Review of National Guidelines (https://doi.org/10.1016/j.ajogmf.2026.102017)

Original synthetic theme music generated locally for this episode.

Episode companion data]]> Mon, 15 Jun 2026 10:08:20 +0000 db51f624e3f39792c0a9ec568fc01d2b32f1743002ba7b4fc73cfded2e5ee55a 6:30 false
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open
2. 0:41 — Headline: Citation and Design
3. 1:22 — Headline: The Result
4. 2:02 — Headline: Limitations and Practice Impact
5. 2:43 — Pivot
6. 3:24 — Round 1: Larrea (Balloon Tamponade Duration)
7. 4:05 — Round 2: Schenone (IUT for Tumor-Related Fetal Anemia)
8. 4:46 — Round 3: Prasad (Preeclampsia Phenotyping)
9. 5:26 — Round 4: Yun (HOMA-IR and PCOS Fertility Outcomes)
10. 6:07 — Close: What to Watch / Still Unsettled

Follow-up links:

• Association of Respiratory Syncytial Virus Vaccination During Pregnancy With Adverse Obstetric and Neonatal Outcomes - Largest post-licensure safety study of RSVpreF in pregnancy; no signal for PTB, stillbirth, SGA, or HDP at recommended gestational window
• Intrauterine Balloon Tamponade Duration for Postpartum Hemorrhage: A Randomized Controlled Trial - First RCT comparing balloon tamponade durations; may shorten standard dwell time if noninferiority confirmed
• Perinatal outcomes following intrauterine transfusion for fetal anemia secondary to fetal or placental tumor: systematic review - Aggregates rare-condition outcome data for IUT in tumor-related fetal anemia; useful for counseling despite limited case numbers
• Pre-Eclampsia Beyond the Binary: Rethinking Phenotypes for Clinical Use - Conceptual framework for preeclampsia phenotyping; may shape future research and guideline development
• Prepregnancy Insulin Resistance and Fertility and Pregnancy Outcomes in Women With Polycystic Ovarian Syndrome - HOMA-IR as preconception predictor of fertility outcomes in PCOS; actionable for risk stratification

Episode companion data]]>
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open
2. 0:41 — Headline: Citation and Design
3. 1:22 — Headline: The Result
4. 2:02 — Headline: Limitations and Practice Impact
5. 2:43 — Pivot
6. 3:24 — Round 1: Larrea (Balloon Tamponade Duration)
7. 4:05 — Round 2: Schenone (IUT for Tumor-Related Fetal Anemia)
8. 4:46 — Round 3: Prasad (Preeclampsia Phenotyping)
9. 5:26 — Round 4: Yun (HOMA-IR and PCOS Fertility Outcomes)
10. 6:07 — Close: What to Watch / Still Unsettled

Follow-up links:

• Association of Respiratory Syncytial Virus Vaccination During Pregnancy With Adverse Obstetric and Neonatal Outcomes - Largest post-licensure safety study of RSVpreF in pregnancy; no signal for PTB, stillbirth, SGA, or HDP at recommended gestational window
• Intrauterine Balloon Tamponade Duration for Postpartum Hemorrhage: A Randomized Controlled Trial - First RCT comparing balloon tamponade durations; may shorten standard dwell time if noninferiority confirmed
• Perinatal outcomes following intrauterine transfusion for fetal anemia secondary to fetal or placental tumor: systematic review - Aggregates rare-condition outcome data for IUT in tumor-related fetal anemia; useful for counseling despite limited case numbers
• Pre-Eclampsia Beyond the Binary: Rethinking Phenotypes for Clinical Use - Conceptual framework for preeclampsia phenotyping; may shape future research and guideline development
• Prepregnancy Insulin Resistance and Fertility and Pregnancy Outcomes in Women With Polycystic Ovarian Syndrome - HOMA-IR as preconception predictor of fertility outcomes in PCOS; actionable for risk stratification

Sources:

• DeSilva et al. - Obstet Gynecol - 2026 - Association of Respiratory Syncytial Virus Vaccination During Pregnancy With Adverse Obstetric and Neonatal Outcomes (https://doi.org/10.1097/aog.0000000000006354)
• Larrea et al. - Obstet Gynecol - 2026 - Intrauterine Balloon Tamponade Duration for Postpartum Hemorrhage: A Randomized Controlled Trial (https://doi.org/10.1097/aog.0000000000006295)
• Schenone et al. - Ultrasound Obstet Gynecol - 2026 - Perinatal outcomes following intrauterine transfusion for fetal anemia secondary to fetal or placental tumor: systematic review (https://doi.org/10.1002/uog.70234)
• Prasad et al. - BJOG - 2026 - Pre-Eclampsia Beyond the Binary: Rethinking Phenotypes for Clinical Use (https://doi.org/10.1111/1471-0528.70289)
• Yun et al. - Obstet Gynecol - 2026 - Prepregnancy Insulin Resistance and Fertility and Pregnancy Outcomes in Women With Polycystic Ovarian Syndrome (https://doi.org/10.1097/aog.0000000000006318)

Original synthetic theme music generated locally for this episode.

Episode companion data]]> Mon, 22 Jun 2026 10:16:49 +0000 e94533aa5610a387d44494b184604bb48087be857cc5745b14e39dbd12b7b8ca 7:33 false
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Clinical Question
2. 0:47 — Headline: Citation and Design
3. 1:35 — Headline: Effect Size and What It Means
4. 2:22 — Headline: Caveat and Practice Impact
5. 3:09 — Round 1: Rondagh — Monochorionic Twins and Anastomosis Burden
6. 3:56 — Round 2: Champion — AC Extremes in Pregestational Diabetes
7. 4:44 — Round 3: Mei-Dan — Spontaneous PTB as Cardiovascular Risk Marker
8. 5:31 — Round 4: Tersigni — Pre-Cerclage Amniocentesis
9. 6:18 — Close: What Remains Unsettled

Follow-up links:

• Prior Stillbirth is Associated with Increased Risk of Subsequent Stillbirth - Establishes that prior stillbirth independently elevates recurrence risk, directly informing surveillance intensity and preconception counseling
• The Role of Placental Anastomoses in Severe Brain Injury After Fetal Demise in Monochorionic Twins - Quantifies the relationship between anastomosis patterns and survivor brain injury, guiding post-demise counseling and imaging timing
• Fetal abdominal circumference and adverse perinatal outcomes in pregnant individuals with pregestational diabetes - Defines clinical utility of AC extremes in pregestational diabetes for identifying fetuses at elevated perinatal risk
• Preterm birth as a risk factor for future maternal cardiovascular morbidity - Supports incorporating spontaneous PTB history into long-term maternal cardiovascular risk assessment
• Amniocentesis before cerclage in asymptomatic women with mid-trimester short cervix: time to consider? - Proposes a framework to distinguish mechanical from inflammatory cervical insufficiency before cerclage placement

Episode companion data]]>
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Clinical Question
2. 0:47 — Headline: Citation and Design
3. 1:35 — Headline: Effect Size and What It Means
4. 2:22 — Headline: Caveat and Practice Impact
5. 3:09 — Round 1: Rondagh — Monochorionic Twins and Anastomosis Burden
6. 3:56 — Round 2: Champion — AC Extremes in Pregestational Diabetes
7. 4:44 — Round 3: Mei-Dan — Spontaneous PTB as Cardiovascular Risk Marker
8. 5:31 — Round 4: Tersigni — Pre-Cerclage Amniocentesis
9. 6:18 — Close: What Remains Unsettled

Follow-up links:

• Prior Stillbirth is Associated with Increased Risk of Subsequent Stillbirth - Establishes that prior stillbirth independently elevates recurrence risk, directly informing surveillance intensity and preconception counseling
• The Role of Placental Anastomoses in Severe Brain Injury After Fetal Demise in Monochorionic Twins - Quantifies the relationship between anastomosis patterns and survivor brain injury, guiding post-demise counseling and imaging timing
• Fetal abdominal circumference and adverse perinatal outcomes in pregnant individuals with pregestational diabetes - Defines clinical utility of AC extremes in pregestational diabetes for identifying fetuses at elevated perinatal risk
• Preterm birth as a risk factor for future maternal cardiovascular morbidity - Supports incorporating spontaneous PTB history into long-term maternal cardiovascular risk assessment
• Amniocentesis before cerclage in asymptomatic women with mid-trimester short cervix: time to consider? - Proposes a framework to distinguish mechanical from inflammatory cervical insufficiency before cerclage placement

Sources:

• Henricks et al. - Am J Obstet Gynecol - 2026 - Prior Stillbirth is Associated with Increased Risk of Subsequent Stillbirth (https://doi.org/10.1016/j.ajog.2026.06.010)
• Rondagh et al. - Am J Obstet Gynecol - 2026 - The Role of Placental Anastomoses in Severe Brain Injury After Fetal Demise in Monochorionic Twins (https://doi.org/10.1016/j.ajog.2026.06.016)
• Champion et al. - Am J Obstet Gynecol MFM - 2026 - Fetal abdominal circumference and adverse perinatal outcomes in pregnant individuals with pregestational diabetes (https://doi.org/10.1016/j.ajogmf.2026.102042)
• Mei-Dan et al. - Am J Obstet Gynecol MFM - 2026 - Preterm birth as a risk factor for future maternal cardiovascular morbidity (https://doi.org/10.1016/j.ajogmf.2026.102019)
• Tersigni et al. - Am J Obstet Gynecol MFM - 2026 - Amniocentesis before cerclage in asymptomatic women with mid-trimester short cervix: time to consider? (https://doi.org/10.1016/j.ajogmf.2026.102014)

Original synthetic theme music generated locally for this episode.

Episode companion data]]> Mon, 29 Jun 2026 10:21:03 +0000 2a134db307c6007b4f00658fe94156e13115fac6ab00741a6f1f9a16ef0d38f8 7:51 false
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Counseling Sentence That Changed
2. 0:44 — Headline: Study Identity and Design Rationale
3. 1:28 — Headline: The Finding and What the Numbers Actually Say
4. 2:12 — Headline: Practice Impact and the Fetal Outcome Gap
5. 2:56 — Pivot + Round 1: Spinillo CP Umbrella Review
6. 3:40 — Round 2: Boelig Cerclage Meta-Analysis
7. 4:25 — Round 3: Ani Cost-Effectiveness Analysis
8. 5:09 — Round 4: Moon-Grady Fetal Cardiac Intervention in Hydrops
9. 5:53 — Close: What Remains Unsettled

Follow-up links:

• Glucagon-Like Peptide-1 Receptor Agonists and Risk of Adverse Maternal Pregnancy Outcomes: A Systematic Review and Meta-analysis - First large-scale meta-analysis addressing maternal safety of GLP-1 RAs in pregnancy; directly relevant to preconception counseling as prescribing expands
• Antenatal, pregnancy and delivery risk factors for infant cerebral palsy: an umbrella review of meta-analyses and systematic reviews - Comprehensive synthesis of 43 CP risk factors with evidence grading; useful reference for structured counseling
• Outcomes with cerclage for short cervix ≤20.9mm before 24 weeks in singletons without prior preterm birth: a focused meta-analysis of randomized controlled trials - Directly addresses a contested clinical indication using RCT-level evidence; informs shared decision-making
• First Trimester Screening for Preterm Preeclampsia in the United Kingdom: A Cost-Effectiveness Analysis - Provides health-economic justification for FMF screening adoption at policy level
• Invasive in-utero cardiac intervention in the hydropic fetus may improve survival: results from the International Fetal Cardiac Intervention Registry (IFCIR) - Largest multicenter dataset on fetal cardiac intervention in hydrops; informs case selection at specialized centers

Episode companion data]]>
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Counseling Sentence That Changed
2. 0:44 — Headline: Study Identity and Design Rationale
3. 1:28 — Headline: The Finding and What the Numbers Actually Say
4. 2:12 — Headline: Practice Impact and the Fetal Outcome Gap
5. 2:56 — Pivot + Round 1: Spinillo CP Umbrella Review
6. 3:40 — Round 2: Boelig Cerclage Meta-Analysis
7. 4:25 — Round 3: Ani Cost-Effectiveness Analysis
8. 5:09 — Round 4: Moon-Grady Fetal Cardiac Intervention in Hydrops
9. 5:53 — Close: What Remains Unsettled

Follow-up links:

• Glucagon-Like Peptide-1 Receptor Agonists and Risk of Adverse Maternal Pregnancy Outcomes: A Systematic Review and Meta-analysis - First large-scale meta-analysis addressing maternal safety of GLP-1 RAs in pregnancy; directly relevant to preconception counseling as prescribing expands
• Antenatal, pregnancy and delivery risk factors for infant cerebral palsy: an umbrella review of meta-analyses and systematic reviews - Comprehensive synthesis of 43 CP risk factors with evidence grading; useful reference for structured counseling
• Outcomes with cerclage for short cervix ≤20.9mm before 24 weeks in singletons without prior preterm birth: a focused meta-analysis of randomized controlled trials - Directly addresses a contested clinical indication using RCT-level evidence; informs shared decision-making
• First Trimester Screening for Preterm Preeclampsia in the United Kingdom: A Cost-Effectiveness Analysis - Provides health-economic justification for FMF screening adoption at policy level
• Invasive in-utero cardiac intervention in the hydropic fetus may improve survival: results from the International Fetal Cardiac Intervention Registry (IFCIR) - Largest multicenter dataset on fetal cardiac intervention in hydrops; informs case selection at specialized centers

Sources:

• Hattler et al. - Obstet Gynecol - 2026 - Glucagon-Like Peptide-1 Receptor Agonists and Risk of Adverse Maternal Pregnancy Outcomes: A Systematic Review and Meta-analysis (https://doi.org/10.1097/aog.0000000000006363)
• Spinillo et al. - Am J Obstet Gynecol MFM - 2026 - Antenatal, pregnancy and delivery risk factors for infant cerebral palsy: an umbrella review of meta-analyses and systematic reviews (https://doi.org/10.1016/j.ajogmf.2026.101990)
• Boelig et al. - Am J Obstet Gynecol MFM - 2026 - Outcomes with cerclage for short cervix ≤20.9mm before 24 weeks in singletons without prior preterm birth: a focused meta-analysis of randomized controlled trials (https://doi.org/10.1016/j.ajogmf.2026.102048)
• Ani et al. - BJOG - 2026 - First Trimester Screening for Preterm Preeclampsia in the United Kingdom: A Cost-Effectiveness Analysis (https://doi.org/10.1111/1471-0528.70294)
• Moon-Grady et al. - Ultrasound Obstet Gynecol - 2026 - Invasive in-utero cardiac intervention in the hydropic fetus may improve survival: results from the International Fetal Cardiac Intervention Registry (IFCIR) (https://doi.org/10.1002/uog.70245)

Original synthetic theme music generated locally for this episode.

Episode companion data]]> Tue, 07 Jul 2026 10:17:35 +0000 0d78957d4617ceebfc9f194054b71aa3ae458d12bb92e80570ba575860e0271f 7:22 false
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Question That Needed a Trial
2. 0:45 — Headline: Citation, Design, and What Earns the Evidence Grade
3. 1:29 — Headline: Effect in Numbers, Then the Caveat
4. 2:14 — Headline: Practice Impact, Honest Version
5. 2:59 — Round 1: Lithium in Pregnancy (Roddy Mitchell)
6. 3:43 — Round 2: Ischemic Placental Disease and Postpartum Brain Morbidity (Ananth)
7. 4:28 — Round 3: Severe Preeclampsia Features and Morbidity Risk (Meng)
8. 5:12 — Round 4: Hadlock Internal Inconsistency (Adu-Bredu)
9. 5:57 — Close: What to Watch, What Is Still Unsettled

Follow-up links:

• Double versus single emergency cervical cerclage combined with vaginal progesterone: a multicenter, non-blinded, randomized controlled trial - First RCT directly comparing cerclage techniques in the emergency setting; informs whether double-level placement justifies added complexity
• Lithium Use in Pregnancy and the Risk of Spontaneous Preterm Birth: An Australian Statewide Retrospective Cohort Study - Large population cohort quantifying lithium-associated risks; directly actionable for preconception counseling in bipolar patients
• Ischemic Placental Disease and Hospitalization for Neurological and Psychiatric Disorders - Highlights maternal brain as target organ of placental dysfunction; supports enhanced postpartum surveillance after severe placental syndromes
• Associations between individual severe features of preeclampsia and severe maternal morbidity - Differentiates risk by specific severe feature; supports moving beyond binary classification toward feature-specific counseling
• Internal Consistency of the Hadlock Estimated Fetal Weight Reference: Methodological Analysis - Identifies systematic discrepancies in widely-used reference at clinically critical thresholds; affects SGA classification decisions

Episode companion data]]>
Juno, Caspar, and any guest voices are AI-generated. Episode text and audio are generated with human-directed software.

Chapters:

1. 0:00 — Cold Open: The Question That Needed a Trial
2. 0:45 — Headline: Citation, Design, and What Earns the Evidence Grade
3. 1:29 — Headline: Effect in Numbers, Then the Caveat
4. 2:14 — Headline: Practice Impact, Honest Version
5. 2:59 — Round 1: Lithium in Pregnancy (Roddy Mitchell)
6. 3:43 — Round 2: Ischemic Placental Disease and Postpartum Brain Morbidity (Ananth)
7. 4:28 — Round 3: Severe Preeclampsia Features and Morbidity Risk (Meng)
8. 5:12 — Round 4: Hadlock Internal Inconsistency (Adu-Bredu)
9. 5:57 — Close: What to Watch, What Is Still Unsettled

Follow-up links:

• Double versus single emergency cervical cerclage combined with vaginal progesterone: a multicenter, non-blinded, randomized controlled trial - First RCT directly comparing cerclage techniques in the emergency setting; informs whether double-level placement justifies added complexity
• Lithium Use in Pregnancy and the Risk of Spontaneous Preterm Birth: An Australian Statewide Retrospective Cohort Study - Large population cohort quantifying lithium-associated risks; directly actionable for preconception counseling in bipolar patients
• Ischemic Placental Disease and Hospitalization for Neurological and Psychiatric Disorders - Highlights maternal brain as target organ of placental dysfunction; supports enhanced postpartum surveillance after severe placental syndromes
• Associations between individual severe features of preeclampsia and severe maternal morbidity - Differentiates risk by specific severe feature; supports moving beyond binary classification toward feature-specific counseling
• Internal Consistency of the Hadlock Estimated Fetal Weight Reference: Methodological Analysis - Identifies systematic discrepancies in widely-used reference at clinically critical thresholds; affects SGA classification decisions

Sources:

• Kosińska-Kaczyńska et al. - Am J Obstet Gynecol - 2026 - Double versus single emergency cervical cerclage combined with vaginal progesterone: a multicenter, non-blinded, randomized controlled trial (https://doi.org/10.1016/j.ajog.2026.07.004)
• Roddy Mitchell - BJOG - 2026 - Lithium Use in Pregnancy and the Risk of Spontaneous Preterm Birth: An Australian Statewide Retrospective Cohort Study (https://doi.org/10.1111/1471-0528.70301)
• Ananth et al. - Am J Obstet Gynecol - 2026 - Ischemic Placental Disease and Hospitalization for Neurological and Psychiatric Disorders (https://doi.org/10.1016/j.ajog.2026.07.008)
• Meng et al. - Am J Obstet Gynecol MFM - 2026 - Associations between individual severe features of preeclampsia and severe maternal morbidity (https://doi.org/10.1016/j.ajogmf.2026.102052)
• Adu-Bredu et al. - BJOG - 2026 - Internal Consistency of the Hadlock Estimated Fetal Weight Reference: Methodological Analysis (https://doi.org/10.1111/1471-0528.70296)

Original synthetic theme music generated locally for this episode.

Episode companion data]]> Tue, 14 Jul 2026 10:17:25 +0000 d23cdd5e3f4b3657b0e88b0872ba388e7c4de048f67c32dfa7198a945fb5b284 7:27 false